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In animal models of renal damage, increasing or decreasing GLP-1 receptor signaling enhances or deteriorates renal function

14 It has been proposed that leptin conveys information to the hypothalamus concerning the amount of energy stored in adipose tissue

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This modification results in a significantly longer half-life, much lower affinity for the IGFBPs and, consequently, around a 3-fold increase in potency [95]

For instance, in male rats that were administered supra-therapeutic doses, an increased GSH level was obtained in addition to elevated SOD and CAT activities

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